strata.MaxCombo - Stratified Max-Combo Test
Non-proportional hazard (NPH) is commonly observed in
immuno-oncology studies, where the survival curves of the
treatment and control groups show delayed separation. To
properly account for NPH, several statistical methods have been
developed. One such method is Max-Combo test, which is a
straightforward and flexible hypothesis testing method that can
simultaneously test for constant, early, middle, and late
treatment effects. However, the majority of the Max-Combo test
performed in clinical studies are unstratified, ignoring the
important prognostic stratification factors. To fill this gap,
we have developed an R package for stratified Max-Combo testing
that accounts for stratified baseline factors. Our package
explores various methods for calculating combined test
statistics, estimating joint distributions, and determining the
p-values.
